CBD or cannabidiol is deprived of psychoactive properties, but it will help with various diseases
Recently, the main topics medical marijuana has been surfacing more and more regularly in foreign media, scientists are trying their utmost to get permissions and funding for research of this type, believing in its promise, and in lots of countries of the planet, decriminalization and legalization are underway.
Most hype now causes a substance such as for example CBD or cannabidiol within the hemp plant. Today it is found anywhere – from food to decorative cosmetics and quite legally purchased cbd gummies for pain uk in online retailers in the form of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it’s healing properties.
Since CBD is a dynamic part of marijuana itself, you will get profit from it by smoking a shared in the old fashioned way. The most important thing is always to be sure that a quality with a predominance of this particular substance, as opposed to THC, is clogged in your joint if you just want to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to manage paranoia.
Let’s try to figure out how this magical cannabidiol works, on the basis of the latest data from the planet of science and the knowledge of consumers using CBD as a medication, and not for fun.
The difference between the consequences of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high as a result, but it’s easy to improve your productivity, relieve anxiety and relieve pain. When working with CBD, thoughts are not confused, memory does not deteriorate, and as a result of muscle relaxation, you may not turn into a vegetable, as is the case with smoking cannabis varieties with a predominance of THC.
If the ratio of those substances is approximately exactly the same, then you will see a small euphoric and the above-mentioned beneficial effects at exactly the same time. At the same time, such negative consequences as paranoia, dry mouth, becoming dry and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which can be brought on by THC, do not occur. Such varieties are most often used as a painkiller.
Although CBD is effective alone, some experts still insist that in conjunction with other active aspects of marijuana, it brings more benefits:
“To attain a much better therapeutic effect, you need a mixture of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, first of all, by too little research data, considering that the field of studying the healing properties of hemp continues to be in its infancy. However the gradual legalization of medical marijuana suggests that scientists will quickly do have more freedom because of their experiments. So contain the fists, hope and believe.
What diseases cannabidiol helps to deal with
Some scientific papers suggest that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope that substance may help pharmaceutical companies to produce effective drugs against many disorders and diseases combined with similar symptoms.
The list of such diseases includes, but is not limited by such pathological conditions:
So far, you will find no full-fledged drugs based on CBD to combat these disorders, but many patients declare that the substance helps them to ease and even completely remove the symptoms.
Recently in the USA, where marijuana continues to be on the list of the most dangerous psychoactive substances, there is a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of that your FDA has confirmed with its tests. Today, Epidiolex is employed to deal with severe kinds of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there have been other drugs on the basis of the aspects of marijuana. For instance, the Belgian company Solvay Pharmaceuticals in 1985 created Marinol (dronabinol), a medication that’s simply a manufactured THC, which will be still used today to improve the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal elements of CBD and THC, to ease muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there’s still not really much data on how CBD has a beneficial effect on the body, scientists still involve some ideas on this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does exactly the same THC. However it interacts with the GPR55 protein secreted in mental performance and peripheral organs. Researchers believe that determines its antispasmodic effect.
In mental performance, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted in one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more regularly than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, based on Ben Wally, head of research at GW Pharmaceuticals.
The relationship of the protein with CBD is confirmed by experiments with genetically modified rodents in which epileptic seizures were caused. Those animals in which GPR55 was present taken care of immediately cannabidiol treatment, and rats without protein continued to see convulsions.
Wally also believes that CBD can subscribe to the desensitization of the TRPV1 protein, which will be involved in the transport of ions and calcium in the torso, which also helps relieve cramping. First, cannabidiol activates this protein, however quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not respond to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance created by the body. Wally believes that cannabidiol suppresses seizures, mainly due to its effect on adenosine, but more experiments are required to confirm this hypothesis.
Such a wide range of areas in which CBD is active allows scientists to suggest that substance may be useful in the treatment of motor disorders, such as for example Parkinson’s disease. And the interaction with serotonin receptors suggests that cannabidiol may be used to deal with depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for example Roger Pertwee, a professor at the University of Aberdeen and the head of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with one of these receptors and proteins means that it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we provides you with a list of popular cannabidiol-dominated varieties so guess what happens to enquire about next amount of time in your telegram supermarket: